The combined analysis demonstrates a prominent elevation in PSME3 mRNA expression across several cancer types, including BLCA, BRCA, CESC, CHOL, COAD, Diffuse Large B-Cell Lymphoma (DLBC), ESCA, GBM, HNSC, KICH, Kidney Renal Papillary Cell Carcinoma (KIRP), Acute Myeloid Leukemia (LAML), Low-Grade Glioma (LGG), LIHC, LUAD, LUSC, Ovarian Cancer (OV), Pancreatic Ductal Adenocarcinoma (PAAD), PRAD, READ, Skin Cutaneous Melanoma (SKCM), STAD, Testicular Germ Cell Tumor (TGCT), Thymoma (THYM), and UCEC. Here, PSME3 is linked to acute myeloid leukemia.