Transcriptome analysis of the lesional skin revealed that approximately two thirds of the genes upregulated in imiquimod-induced dermatitis were also induced in anisomycin-induced dermatitis whereas some genes, such as Defb3, S100a8/a9, and Il19, were dominant in the imiquimod-induced dermatitis and others including Defb4, Mmp13, and Il24 were dominant in the anisomycin-induced dermatitis (4). The gene discussed is IGKV1D-22; the disease is skin disorder.