NFKB1 and hepatocellular carcinoma: Clinical observations align with experiments conducted on HCC cell lines in vitro, revealing that IL-37-transfected HepG2 HCC cells significantly suppress the expression of NFκB (31), which plays a crucial role in hepatic injury, fibrosis, and HCC (36) by regulating inflammation and cell death, as emphasized by studies demonstrating that its depletion leads to spontaneous liver injury, fibrosis, and HCC (37).