Given that miR-27b-3p reverses multi-drug resistance in breast cancer by targeting CBLB/GRB2 (29) in vitro and in vivo, the expression of miR-27b-3p in HCC tissues was investigated, revealing an upregulation that displayed an inverse relationship with IL-36α in HCC, potentially mediated through CXCL1 in HCC cells (28). The gene discussed is GRB2; the disease is hepatocellular carcinoma.