The conjugation between HSA-MnO2 and tumor antigenic peptides can be achieved through the assistance of succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC), which is a bifunctional coupling agent containing N-hydroxysuccinimide ester and maleimide [[35], [36], [37]]. The gene discussed is ALB; the disease is neoplasm.