NFKB1 and diabetes mellitus: IL-6 produced in the late stage of diabetes can regulate the JMJD3 of macrophages through JAK1,3/STAT3 signals, thus inducing inflammatory pathways such as NF-κB, and STING is regulated by it. Inhibiting the expression of JMJD3 can reduce the expression of inflammatory factors, thus speeding up wound healing.