The EZH2-HMGA1-USP7 complex regulates the formation of CCF, and CCF activates cGAS, but USP7 is required to de-ubiquitinate cGAS and stabilize cGAS, EZH2 can promote breast cancer metastasis through cGAS-STING pathway activated by CCF. The gene discussed is HMGA1; the disease is breast carcinoma.