IL-6 produced in the late stage of diabetes can regulate the JMJD3 of macrophages through JAK1,3/STAT3 signals, thus inducing inflammatory pathways such as NF-κB, and STING is regulated by it. Inhibiting the expression of JMJD3 can reduce the expression of inflammatory factors, thus speeding up wound healing. This evidence concerns the gene STING1 and diabetes mellitus.