In obesity, the activation of TBK1 will inhibit NF-κB-inducing kinase (NIK), thus inhibiting NF-κB from achieving the effect of reducing inflammation, showing that TBK1 plays a bidirectional role in energy storage and metabolism to achieve a balance between energy metabolism and inflammation [74–76]. This evidence concerns the gene TBK1 and obesity due to melanocortin 4 receptor deficiency.