Analysis of liver samples from patients with NAFLD showed increased expression of STING/p-TBK1 in all cells compared to the normal control group, and predominantly in macrophages, especially in the porta hepatis of patients with Non-alcohol-associated fatty liver (NASH) fibrosis compared to the healthy control group [231,232]. This evidence concerns the gene TBK1 and metabolic dysfunction-associated steatohepatitis.