In this study, we investigated the anti-tumor effect and immunomodulatory activity of PF combined with Sor in an H22 hepatoma-bearing mouse model by evaluating tumor growth and analyzing the expression of Ki-67 (tumor proliferation), TUNEL (tumor apoptosis), as well as T-cell subsets of CD4+ and CD8+, IL-2 and IFN-γ production, and tumor-specific CTL response. This evidence concerns the gene CD8A and neoplasm.