To corroborate the degree of enrichment of UBE2S in pan-cancer signaling pathways, we utilized the results of GSEA analysis to demonstrate that the most crucial enriched signaling pathways (P < 0.05) were the DNA repair signaling pathway, DNA damage pathway, cell cycle signaling pathway, inflammation, and apoptosis (Fig. 8C)·In summary, the impact of UBE2S on the DNA repair, DNA damage, and the cell cycle may potentially govern the progression of malignancy and unfavorable survival consequences in individuals diagnosed with pancreatic cancer. Here, UBE2S is linked to familial pancreatic carcinoma.