Presently, mounting evidence suggests that UBE2S impacts cancer progression through multiple mechanisms, such as NF-κB, Cell cycle, SOX6-Catenin, Wnt/β-catenin, PI3K/AKT/mTOR, PTEN-AKT, and VHL/HIF-1α/STAT3 (Fig. 9). This evidence concerns the gene STAT3 and cancer.