AKT1 and polycystic kidney disease: Comparable metabolic shifts were observed in atrophic TECs associated with polycystic kidney disease and ischemia-reperfusion injury, processes mediated by activation of the Akt/phosphatidylinositol 3-kinase/mammalian target of rapamycin complex 1 (Akt/PI3K/mTORC1) signaling pathway (Lan et al., 2016; Podrini et al., 2020).