When we analyzed the core pluripotency master regulators (the Yamanaka factors (34); Fig. 1E) and the breast cancer-specific indices of the degree of oncogenic dedifferentiation (identified using a machine learning algorithm (35); Fig. 1F), the autonomous WT cells maintained these signatures despite serum depravation; GIV-KO cells did not. This evidence concerns the gene CCDC88A and breast carcinoma.