CCDC88A and neoplasm: For example, all gene signatures derived from isolated distinct single-cell clones from the SUM149PT human breast cell line spanning the E↔EM1-3↔M1-2 spectrum, previously characterized for diverse migratory, tumor-initiating, and metastatic qualities (37), were induced in the autonomous WT, but suppressed in the GIV-KO cells during serum depravation (Fig. 2A and B).