EGFR and neoplasm: By demonstrating that a secretion-coupled-sensing machinery at the Golgi (29, 30) that requires scaffolding by GIV is essential for tumor cells to achieve a state of self-sufficiency in EGFR/ErbB signaling, it is not unusual for us to find that such a state is endowed with a multitude of pro-oncogenic biological processes that are known to be supported by EGFR/ErbB signals, including cell anchorage-independent cell growth, stemness, EM plasticity, and metastasis (66).