Evidence cannot be conclusive for the role of ASIC1a in regulating the EPR in PAD; however, based on the previous findings we think that there is a discrepancy in the activities of ASIC1a and ASIC3 in IB4− versus IB4+ DRG neurons, particularly their activation with a low pH following I/R and FAO (Li et al., 2023). Here, ASIC3 is linked to peripheral arterial disease.