ASIC3 and peripheral arterial disease: Our first data of the present study demonstrated that FAO increased NGF (Figure 1a) and its receptor TrkA in DRGs (Figure 1c) as well as protein expression of ASIC3 but not ASIC1a (Figures 2a,b), suggesting that NGF is likely to play a role in regulating the activities of ASIC3 in the DRG neurons of experimental PAD rats.