The inflammatory pathways via TNFα, TLR4, NFκB, and NLRP3, improves insulin resistance (Akash et al., 2018; Arkan et al., 2005; Moller, 2000; Shi et al., 2006; Vandanmagsar et al., 2011) and these pathways are the targets of metformin which will be mentioned in following sections. Here, TNF is linked to Insulin resistance.