CD8A and neoplasm: In contrast, the interaction between endothelial cells and CD8 + T cells is lost in 4T1 liver metastases (correlation coefficient = -0.1667) compared to the primary tumour, with a concomitant increase in interactions between endothelial cells and neutrophils (correlation coefficient = 0.4064) and total neutrophil abundance (Fig. 5J-KT1: 0.19%; 4T1-liver: 0.88%).