The Tyr::CreER/BRafCA/+/Ptenlox/lox transgenic mouse is a well-described murine model of melanoma, which allows 4-hydroxytamoxifen-inducible melanocyte-targeted BRAFV600E expression and simultaneous PTEN inactivation (referred to hereafter as BRAFV600E/PTEN−/−). The gene discussed is PTEN; the disease is melanoma.