For example, the lncRNA pan-cancer lncRNA activating NCOR2 responsive to E2F1 (PLANE) regulates an alternative splicing program to promote cancer pathogenesis in the pan-cancer context [21], whereas the lncRNA glycoLINC (gLINC) acts as a backbone to assemble a glycolytic metabolon, thus promoting glycolysis to enable cancer cell adaptation to metabolic stress [29]. The gene discussed is E2F1; the disease is cancer.