We also compared the expression of CXCL12 in endothelial cells and found that endothelial cells in obese tumor samples exhibited the highest level of CXCL12 expression (Fig. 5F), pointing towards the possibility that CXCL12 secreted by endothelial cells in obese CRC could attract IgG+plasma cells expressing CXCR4. This evidence concerns the gene CXCL12 and neoplasm.