At the same time, in early-stage BC (Fig. 6A-E), the AUC of SNORD16 combined CEA increased from 0.747 to 0.805, the AUC of SNORA73B increased from 0.730 to 0.789, the AUC of SCARNA4 increased from 0.674 to 0.749, and the AUC of SNORD49B increased from 0.668 to 0.739. Here, CEACAM5 is linked to breast cancer.