Diabetes significantly elevated GFAP+ immunoreactivity in FKNKO mice (33.82 ± 4.54), which was decreased with rAAV–sFKN (23.51 ± 3.02, Student’s t test p < 0.01) but not rAAV–mFKN (30.20 ± 3.36). The gene discussed is GFAP; the disease is diabetes mellitus.