According to the previous research reports, DND1 can regulate PI3K/AKT, TGF, WNT, and other signaling pathways and play a role in relevant evidence (Yamaji et al. 2017); we speculate that the effect of DND1 on the biological function of melanoma may also be achieved by regulating the PI3K/AKT signaling pathway. This evidence concerns the gene DND1 and melanoma.