To investigate the effect of circFCHO2 on the biological function of melanoma, we transiently transfected human melanoma A375 and MV3 cell lines with circFCHO2 interference fragment (siRNA), and transfected and constructed A375 and MV3 cell lines stably overexpressing circFCHO2 with lentivirus vector without affecting the expression of FCHO2 mRNA. This evidence concerns the gene FCHO2 and melanoma.