IFNG and cancer: On the other hand, MSC-derived EVs inhibit B-lymphocyte proliferation79 and display immunosuppressive effects by suppressing natural killer (NK) cell activity and interferon gamma (IFN-γ) production.80 In summary, EVs released by stem cells, including ESCs and MSCs, have diverse functions and can influence the behavior and characteristics of recipient cells in various contexts, including embryonic development, tissue repair, cancer progression, and immune modulation.