CCN1 and breast cancer: Proteins such as EDIL3, FAK, fibronectin, caveolin-1, Cyr61, ephrin type-A receptor 2, DnaJ homolog subfamily A member 1, polyadenylate-binding protein 1, and neuropilin-1 have been found to be expressed at higher levels in serum EVs of triple-negative BC (TNBC) patients compared to other BC subtypes, suggesting their relevance as biomarkers distinguishing between different BC subtypes.233,234 miRNAs in EVs have shown special potential as biomarkers for identifying HCC.