Recent studies have revealed that TDEVs can reprogram cancer-infiltrated dendritic cells (DCs) toward a tumor-promoting phenotype, thereby mediating tumor immune suppression.293 The maturation and function of DC cells depend on the composition of their contents, but TDEVs content, including HSP, TLR, HLA g,294 S100A8, S100A9, Annexin A1,292 PGE2,295 TGFβ1,296 or miRs,297 suppress DC maturation. Here, S100A8 is linked to neoplasm.