CASP3 and gastric cancer: TDEVs miR-21-5p promotes GC peritoneal metastasis by inducing EMT and targeting SMAD7.146 Under pathological conditions, EVs carrying miR-15b-3p enhance tumorigenesis and malignant transformation by suppressing the NYDLT1/Caspase-3/Caspase-9 pathway and apoptosis in GC.147 EVs also promote the growth and metastasis of GC by transporting N-recognin 2 (UBR2), a component of the ubiquitin protein ligase E3, to GC cells.