STING1 and neoplasm: By blocking CD47 expression in tumor cells, TEVs preferentially accumulate and export tumor mitochondrial DNA, which activates STING signaling in nearby DCs, thereby enhancing antitumor immunity.354,355 Additionally, the administration of CD40L-enriched EVs (CD40L-EXO) into LC has effectively enhanced DC maturation and the activity of antitumor T cells.