In a study involving HNSCC patients, specific biomarker candidates, including FAS, RET, STAT5, TNFRSF1B, WNT1, ABCB1, CASP5, CCND1, FGF1, ABL1, BCL2L1, PRIM1, CD4, HSP90AA1, and HSP90AB1, were detected in EVs from pre-treatment tumor tissues. This evidence concerns the gene HSP90AB1 and head and neck squamous cell carcinoma.