For instance, MAGE-1 and HER-2/neu mRNA were significantly overexpressed in EVs from five patients with stage IV GC.132 Abundant expression of miR-21, miR-30a, miR-1290, and miR-1246 has been found in EVs derived from GC stem-like cells.133,134 Deep sequencing of RNAs from a cohort of GC patients revealed high expression of miR-217, which negatively impacts CDH1 levels and subsequent cancer cell proliferation.135 LncRNA ZFAS1 and miR-423-5p were upregulated in GC cells, tumor tissues, and serum in GC patients’ EVs. Here, ERBB2 is linked to gastric cancer.