PCGEM1 and gastric cancer: Under hypoxic conditions, overexpression of lncRNA PCGEM1 in EVs reduced the degradation of SNAI1 in GC, inducing the invasion and metastasis of GC cells.151 An in vitro study demonstrated that EVs derived from highly metastatic diffuse GC cells and carrying miR-193b induce chemokine production in fibroblasts known as CAFs.