CDCP1 and cancer: The researchers used an unbiased proteomic strategy to identify other platelet players that mediate blood-vascular cell interactions in thrombogenesis.384–386 They found dysregulation of proteins involved in cytoskeleton dynamics and cell adhesion processes, such as CUB domain-containing protein-1 (CDCP1) and kindlin-3 (FERMT3).387 CDCP1 activates β1-integrin and regulates adhesion in cancer settings, while FERMT3/Kindlin-3 regulates platelet integrin activation, adhesion, and aggregation.388–390 A transmembrane receptor called tissue factor (TF) is the main catalyst for blood coagulation.