HGF and gastric cancer: High expression of CD44v6, TGF-β1, and CD97 plays a central role in forming premetastatic niches in the GC and regional lymph nodes.137–139 EGFR derived from GC cells and integrin αvβ5 EVs has been associated with liver metastasis.140 EGFR, when transported via EVs to the liver, promotes liver-specific metastasis in GC through liver miR-26a/b and HGF signaling.140 By delivering c-Myc, TDEVS increased GC cell proliferation, invasion, and migration.