Tetraspanins, a group of plasma membrane proteins highly expressed in EVs, have been found to influence TME by altering the proportion of stromal and immune cells present.240,241 CD151, a tetraspanin, promotes tumor invasion in BC and prostate cancers and enhances trans-endothelial migration by inhibiting ERBB2 and overexpressing FAK, ERK, EGFR, and PKCα molecules. This evidence concerns the gene PTK2 and breast cancer.