Similar attenuation occurred when inhibiting the JAK2/STAT3 pathway by AZD-1480 (Fig. 6b), indicating the role of IL-6/JAK2/STAT3 signaling in up-regulating c-MYC and activating NOTCH pathway during co-culture of SCLC cells and fibroblasts. This evidence concerns the gene MYC and small cell lung carcinoma.