The LFS‐based apoptosis of PKF is consistent with several studies conducted on tumors, which have reported that abnormal cells are more sensitive to mechanical stress.[36, 37] The current understanding of how mechanical stress leads to an elevation in cytoplasmic calcium levels, subsequently triggering tumor cell apoptosis, remains insufficient.[38] In this study, we propose that one possible reason is that the expression of Piezo1 is higher in PKF, which enables them to be more sensitive to ultrasound stimuli. Here, PIEZO1 is linked to neoplasm.