PIEZO1 and keloid: Previous studies have reported overexpression of Piezo1 in myofibroblasts of human and rat hypertrophic scar (HS) tissues, and Piezo1 plays an important role in the process of mechanical stretch‐promoted HS formation.[25] To investigate whether the expression of Piezo1 increased in keloids, we compared the expression levels of Piezo1 in keloids and normal scars based on single‐cell RNA‐seq (scRNA‐seq) data previously published by Deng et al.[19] As a mechanosensitive ion channel, Piezo1 was more frequently expressed in endothelial and lymphatic endothelial cells (Figure 1A–C).