ZC3H12A and pulmonary fibrosis: In addition, the proliferation and migration of fibroblasts, which are signaling events in the development of pulmonary fibrosis, were enhanced by MCPIP1 in this model.14, 15, 16 Recent studies have also shown that a lack of MCPIP1 in macrophages aggravates chronic renal inflammation and promotes the loss of tubular epithelial cells and renal fibrosis upon kidney ischemia‒reperfusion injury.17