ACTA2 and squamous cell carcinoma: Moreover, in Mcpip1EKO mice with epidermal Zc3h12a deletion, chemically induced squamous cell carcinoma is characterized by enhanced expression of Tgfb1. 28Our results prove that the overexpression of MCPIP1 in LX-2 cells decreases the expression of TGFB1, ACTA2, and COL1A1 and therefore α-SMA protein levels.