GP5 and neoplasm: High-grade PIN lesions had the highest mean RS of 6.1 (SD 3.0) and the RS scores of invasive tumor glands were as follows: GP3: RS 4.6 (SD 3.4); GP4: RS 4.3 (SD 4.1) and GP5: RS 5.5 (SD 4.3) (Fig. 3b).