Zhou et al. investigated how lncRNA PVT1 regulates autophagy-induced gemcitabine in pancreatic cancer cells and showed that PVT1 activated Wnt/β-catenin and enhanced autophagic activity leading to the resistance of cancer cells to gemcitabine (Zhou et al. 2020). This evidence concerns the gene PVT1 and familial pancreatic carcinoma.