RAB5A and cancer: According to Chen et al. while PLCA8-induced autophagy inhibition promoted breast cancer resistance to adriamycin, activation of autophagy using rapamycin significantly improved the response of breast cancer to adriamycin treatment (Chen et al. 2021).In gastric cancer, autophagy suppression by Rab5a induces resistance of cancer cells to cisplatin treatment but knockdown of Rab5a activates autophagy and enhances the sensitivity of cancer cells to cisplatin treatment (Xu et al. 2018).