Inactivating germline mutations of the PRKAR1A gene have been reported in the literature in a majority of patients with CNC.36 In contrast to the genetic abnormalities observed in CNC patients, few single gene mutations leading to sporadic cardiac myxoma have been found to date.16,18 Moreover, the genetic basis of sporadic cardiac myxoma has yet to be fully elucidated. This evidence concerns the gene PRKAR1A and Carney complex.