PRKAR1A and Carney complex: Instead, the majority of cardiac myxomas (90%) occur sporadically.16 Whether a mutation in the PRKAR1A gene is the cause of sporadic cardiac myxomas in patients without a relevant family history and without CNC is still controversial.4,17,18 In this study, mutations of PRKAR1A were studied in seven cases of sporadic cardiac myxomas that occurred in the absence of a family history of cardiac myxomas and without CNC.