The PRKAR1A gene is a tumor suppressor gene that encodes a PKA regulatory 1α subunit.27 Previous research has demonstrated that PRKAR1A mutation is the cause of CNC in approximately 70% cases and localized on Chr 17 q22-24.6,28 However, whether PRKAR1A mutation is involved in the pathogenesis of sporadic cardiac myxoma in the absence of a family history or CNC remains a controversial topic. The gene discussed is PRKAR1A; the disease is Carney complex.