Sun et al and Jehn et al in two different study populations reported that subjects with higher levels of ferritin were at higher risk of MetS and type 2 diabetes.23,24 Low ferritin is an indicator of iron deficiency anemia.1 Furthermore, a recent study on male blood donors revealed that serum levels of ferritin and iron are adversely associated with insulin sensitivity,25 which is a key element of MetS.26 Considering iron deficiency as the main cause of anemia in our subjects based on MCV and MCHC, we showed the negative association between anemia and MetS. The gene discussed is INS; the disease is Iron deficiency anemia.