Li et al reported that FOXD4 was consistently found to have diagnostic and prognostic value in colonic cancer and to be linked to the nuclear matrix, Rap1 signaling pathway, RNA transportation, and VEGF signaling framework.63 The growth of gastric cancer is connected with aberrantly expressed FOXS1, which has the potential to serve as a biomarker for both diagnosis and prognosis.50 Overall, these findings indicate that these FOX genes may be crucial targets for the therapeutic implications of COAD. This evidence concerns the gene FOXD4 and colonic neoplasm.