After we identified that the expression of three FOX genes (FOXD4, FOXH1, and FOXS1) are independent prognostic factors and regulate tumor immunity in COAD, we investigated the Spearman’s correlation of these three genes with various cancer-associated pathways activity (R > 0.20 and P < 0.01). The gene discussed is FOXS1; the disease is colon adenocarcinoma.