The FOX genes are associated with immunoregulation, including regulating CD4 + T cell tolerance, thymic development, macrophage differentiation, natural killer cell effector function, and T cell activation.4 The FOXOs regulate the immune system by modulating tumor and stromal cells.12 Martin et al showed that the FOXP3 (OMIM number: 300292) is an immunosuppressive marker in human malignancies.13 These studies provided crucial information about the oncogenic roles of FOX genes associated with cancer onset, development, metastasis, tumor immunity, and signaling pathways in human malignancies. The gene discussed is CD4; the disease is neoplasm.