Farhan et al. reported that the FOXO signaling pathways are substantial therapeutic targets in cancer treatment strategy.43 Uddin et al. established that the various pathways in cancer, small cell lung cancer, p53, apoptosis, and notch signaling processes are enriched in the colon tumor microenvironment.44FOXO subfamily members regulate the PI3K-AKT molecular pathway.7 The disruption of TGF-β signaling is crucially correlated with CRC tumorigenesis and progression.45 Altogether, the FOX gene-associated PPI network-mediated signaling cascades may be associated with colorectal carcinogenesis. Here, TGFB1 is linked to colonic neoplasm.