TNF and Cowden disease: On the other hand, Kedia et al did not report a significant difference in treatment with oral corticosteroids and anti-TNF therapies between elderly-onset CD patients and other CD cases.19 The difference in these drugs among the elderly-onset group could be attributed to either a less severe disease course or higher rate of drug-related complications.36 Disease activity during the previous six months and two weeks were similar between early- and elderly-onset CD patients.