Also, HMGN1 expression was significantly and positively linked to MSI in CHOL, BLCA, HNSC, COAD, KIRP, Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (DLBC), PRAD, LGG, Rectum adenocarcinoma (READ), SKCM, SARC, STAD, THCA, TGCT, and UCEC (p<0.05), but it showed a significant and negative relationship with CESC. This evidence concerns the gene HMGN1 and rectum adenocarcinoma.