However, in the MR analysis adjusted for variables, the association between the ApoB/ApoA1 ratio and PAD, cerebrovascular diseases (including TIA and ischemic stroke), non-rheumatic valve diseases, atrial fibrillation and atrial flutter diseases were significantly weakened (all P>0.05) (Fig. 5, Additional file, Table S7). This evidence concerns the gene APOA1 and ischemic stroke.