However, the changes in the ApoB/ApoA1 ratio did not show a significant genetic association with genetic variations related to risk factors such as HbA1c, fasting glucose, fasting insulin levels, overweight, waist-to-hip ratio, coffee intake, alcohol consumption, alcohol intake frequency, smoking, depression, insomnia, sleep apnea, and sedentary behavior (Fig. 4, Additional file, Table S5, Figure S3). This evidence concerns the gene INS and major depressive disorder.