There was no evidence showing ApoB/ApoA1 was associated with the incidence rates of hypertension, pulmonary embolism, cardiomyopathy, intracerebral hemorrhage, subarachnoid hemorrhage, DVT of the lower extremities, T2DM, obesity, NAFLD, CKD, although the MR analysis of DVT of lower extremities, hypertension showed PFDR-values less than 0.05 in Weighted median results (Fig. 2, Additional file, Table S5, Figure S1). This evidence concerns the gene APOB and chronic kidney disease.