The ApoB/ApoA1 ratio had a significant causal relationship with the incidence rate of heart failure in IVW and MR-PRESSO analysis (IVW, OR = 1.090, 95%CI = 1.012,1.174, PFDR=0.038; MR-PRESSO, PFDR=0.045) (Fig. 2, Additional file, Table S5, Figure S1), however, P-values were greater than 0.05 in MR Egger and Weighted median results. Here, APOB is linked to heart failure.