Also, the genetically predicted the ApoB/ApoA1 ratio had a significant positive association with the occurrence rates of PAD, non-rheumatic valve diseases, atrial fibrillation and atrial flutter (PFDR<0.05 in at least three MR methods in the four methods) (Fig. 2, Additional file, Table S5, Figure S1). The gene discussed is APOA1; the disease is heart valve disorder.