There was no evidence showing ApoB/ApoA1 was associated with the incidence rates of hypertension, pulmonary embolism, cardiomyopathy, intracerebral hemorrhage, subarachnoid hemorrhage, DVT of the lower extremities, T2DM, obesity, NAFLD, CKD, although the MR analysis of DVT of lower extremities, hypertension showed PFDR-values less than 0.05 in Weighted median results (Fig. 2, Additional file, Table S5, Figure S1). The gene discussed is APOA1; the disease is obesity due to melanocortin 4 receptor deficiency.