APOB and major depressive disorder: However, the changes in the ApoB/ApoA1 ratio did not show a significant genetic association with genetic variations related to risk factors such as HbA1c, fasting glucose, fasting insulin levels, overweight, waist-to-hip ratio, coffee intake, alcohol consumption, alcohol intake frequency, smoking, depression, insomnia, sleep apnea, and sedentary behavior (Fig. 4, Additional file, Table S5, Figure S3).