HSD17B13 and metabolic dysfunction-associated steatotic liver disease: In addition, several other genetic determinants of NAFLD have been identified, including hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) [25], phosphatase 1 regulatory subunit 3B (PPP1R3B) [26], immunity-related GTPase M (IRGM) [27] and Lpin1 [28].