After further adjusting for other lifestyle factors in model 2, five of the validated proteins (osteoclast-associated immunoglobulin-like receptor [HOSCAR], placenta growth factor [PGF], thrombospondin-2 [THBS2], ST2 protein, and tumor necrosis factor receptor 1 [TNF-R1]) lost significance in the group without T2D. The gene discussed is THBS2; the disease is type 2 diabetes mellitus.