PTH and postmenopausal osteoporosis: in vivo experiments have reported that impaired γ-carboxylation of OC, induced by vitamin K insufficiency, could attenuate the enhancing effect of PTH1–34 therapy on the biomechanical recovery of osteotomized bone in rats, whereas combined treatment with Vit K2 and TPTD may be more effective than monotherapy for postmenopausal osteoporosis, perhaps through the increase in OC and the activation of Ob.S (the number of osteoblasts attached to the surface of the cancellous bone) [38], which was verified in our results.