The low expression of HLA-G in trophoblast cells has been validated to be a contributing factor to recurrent miscarriage, whereas glucocorticoids could potently reverse the phenomenon and enhance HLA-G expression in a concentration-dependent manner, hinting that glucocorticoids might be beneficial to protecting the fetus from immune system attack in patients with recurrent miscarriage [53]. This evidence concerns the gene HLA-G and spontaneous abortion.