Besides, serum sHLA-G levels exhibited remarkable diagnostic value for thyroid cancer (AUC = 0.925), which was linked to clinicopathological features including tumor size, lymph node metastasis, and degree of differentiation, and showed significant negative correlation with 1 year and 3 year survival rates [138]. The gene discussed is HLA-G; the disease is metastatic malignant neoplasm in the lymph nodes.