HLA-G/ILT-4 signaling was crucial to tumor angiogenesis, documented with that the interplay between HLA-G and ILT4 boosted the expression of VEGF-C in clear cell renal cell carcinoma and NSCLC, thereby facilitating the tumor growth and lymphatic metastasis [105, 237, 238]. The gene discussed is LILRB2; the disease is clear cell renal carcinoma.