Further analysis revealed that down-regulated DEGs were significantly enriched in Oxidative phosphorylation, Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease (Figure S3, Table S4); up-regulated DEGs were significantly enriched in ECM-receptor interaction, Protein digestion and absorption, Focal adhesion, and PI3K-Akt signaling pathway (Figure S4, Table S5). Here, AKT1 is linked to early-onset autosomal dominant Alzheimer disease.