Among these models that use the rate of postnatal weight gain to predict worse ROP are the WINROP algorithm (weight, insulin-like growth factor 1 (IGF-1), neonatal retinopathy of prematurity risk algorithm), the Children’s Hospital of Philadelphia postnatal weight gain, birth weight (BW), and gestational age (GA) ROP risk model(CHOP-ROP), the Colorado-retinopathy of prematurity model (Co-ROP), The Digital ROP model (DIGIROP), The Postnatal Growth and ROP study model (G-ROP) and The Alexandria retinopathy of prematurity model (Alex-ROP) [10]. This evidence concerns the gene IGF1 and retinopathy of prematurity.