CD4 and Granuloma: The granulomas were composed of abundant CD3+ (Fig. 4i), CD4+ (Fig. 4j) and CD8+ (Fig. 4k) T cells but less CD20+ B cells (Fig. 4l) and showed a focal pSTAT1 expression in the nuclei of multinucleated giant cells (Fig. 4m) and CD4+ and CD8+ T cells (Fig. 4n, o).