RICTOR and infection: Mostly researcher reported about the bacterial polysaccharide intercellular adhesin (PIA), a polymer of β-(1 → 6)-linked glucosamine substituted with N-acetyl and O-succinyl constituents produced by other staphylococcus species like Staphylococcus epidermidis or Staphylococcus aureus which is the main constituents of the part of their extracellular matrix in biofilms and known to be responsible for biofilm associated infections and immune evasion [55, 56].