At this point, we analyzed the medians of some MM prognostic predictors, such as albumin, beta-2 microglobulin, LDH and percentage of bone marrow plasma cell infiltration (BMPC), both in whole cohort and in the three different isotypes, and therefore, we examined the trend of each parameter in relation to the median of singly prognostic predictor (Supplementary Table 2). Here, B2M is linked to Miyoshi myopathy.