Parallel cellular assays for extracts derived from a CBD, PSP, PiD and a fourth independent AD (AD4) patient case (Supplementary Table 1) once more validated the known importance of PHF6, as the ΔPHF6 deletion resulted in a ubiquitous loss of cellular seeding regardless of the source of the tau seeds (Supplementary Fig. 3). This evidence concerns the gene PHF6 and Alzheimer disease.