The intracellular deposition of the protein tau as amyloid fibrils characterizes a heterogeneous group of more than 20 neurodegenerative diseases, called tauopathies, including Alzheimer’s disease (AD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), among others1. This evidence concerns the gene MAPT and Classical progressive supranuclear palsy.