CD274 and nasopharyngeal carcinoma: The efficacy of immune checkpoint blockade has been confirmed in recurrent or metastatic (R/M) NPC in the first-, second-, and later-line settings11,12, which is likely associated with intrinsic properties of NPC, including the abundant lymphocytic infiltrations and upregulation of programmed cell death-ligand 1 (PD-L1)13–16.