TNF and hepatocellular carcinoma: Enriched HALLMARK pathways related to inflammatory responses including TNF-α signaling and interferon alpha response were commonly observed in AXL-low patients and Sen samples (Fig. 3A), suggesting an overlapping phenotype between AXL-high and TKI-resistant HCC and a potential contributing role of AXL in the immunosuppressive phenotypes of TKI-resistant HCC.