CSPG4 has been suggested to interact with a number of proteins, such as type V and VI collagens in rat glial B49 and B111 cells (22), PDGFα receptor (23), multi-PDZ domain protein MUPP1 in CSPG4-overexpressing glioma U251 cells (24), galectin-3 (25), and syntenin-1 (26). Here, CSPG4 is linked to central nervous system cancer.