Other known CS-modified proteins, such as SMC3, aggrecan, neurocan, versican, brevican, decorin, and biglycan, which are suggested to be expressed in glioma, melanoma, breast, pancreatic, and prostate cancer (17, 18, 19), were analyzed in detail with our study (Table S1 and Fig. S8) and found that only SMC3 was identified as an upregulated CSPG family protein in GICs besides the CSPG4. This evidence concerns the gene SMC3 and central nervous system cancer.