While previous studies were also able to show retinal changes in people with PSP and tau-associated frontotemporal degeneration [1, 6, 7], this study is the first to suggest that the changes in OCT parameters occur very early in the disease course of PSP and might thus be feasible as biomarkers for early diagnosis and prognosis. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.