In addition, to reveal the underlying relationship between NAT10 and miRNA biogenesis, we analyzed the relationship between NAT10 with miRNA processing machineries [53] in clinical TCGA lung cancer tissues, and showed that NAT10 was positively correlated with DGCR8, DROSHA, XPO5, DICER1, AGO2 and TARBP2 (Spearman correlation coefficient (R) values of between 0.36 and 0.67) (Fig. S7e). This evidence concerns the gene XPO5 and lung cancer.