Genes in cluster 8 (GSTO2, LRRC34), 9 (CLPTM1L) and 10 (CTSS, SETDB1, ANXA9, GOLPH3L, HORMAD1, PPIL3, CASP9, ALS2CR12) underlie the association between melanoma and cancers. The gene discussed is CASP9; the disease is melanoma.