Interestingly, the patient carrying the germline variant BRCA1 c.1387A>T (p.Lys463*), at the BRCA1 Ovarian Cancer Cluster Region, classified as likely pathogenic (accordingly to ACMG) and presenting LOH in the tumoral tissue, did not present familial or personal cancer history consistent with HBOC. Here, BRCA1 is linked to cancer.