In addition, as is already known, existing proteins as ICH biomarkers (for example, vascular cell adhesion molecule 1 (VCAM-1), brain natriuretic peptide (BNP) and MMP-9) involved in microglial activation, endothelial dysfunction, cell metabolism disorders, etc., the expression of which should be very clearly regulated in the cell by miRNA. The gene discussed is NPPB; the disease is endothelial dysfunction.