For instance, BDNF treatment (1-week intravenous injection, 5.7 nmol/kg) in combination with ADTC5 (10 μmol/kg), a molecule facilitating the transport of BDNF across the BBB, induced a marked rise in the cognitive performance and NOR assessments of transgenic AD mice [233]. The gene discussed is BDNF; the disease is Alzheimer disease.