BRCA2 and cancer: Detailed examination of the pleiotropic loci identified numerous RNY genes, pseudogenes, and derived sequences (total n = 118) mapped in a region ± 50 kb from the pleiotropic variants across the cancer studies, with the exception of three settings: breast cancer caused by pathological variants in BRCA2, and gastroesophageal and kidney cancers (Fig. 5a).