Moreover, AF-treated Akr1a1−/− mice showed a significant loss in body weight (-1.42 g on average) at the end of alcohol feeding compared to their initial weight; however, in the other groups, body weights were significantly increased (WT + PF: +3.66 g; WT + AF: +2.19 g; Akr1a1−/−+PF: +3.66 g on average). Here, AKR1A1 is linked to atrial fibrillation.